| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 16-9-25 18:45 | Athletic Bilbao | FC Arsenal | -:- |
| 16-9-25 18:45 | PSV Eindhoven | Royale Union Saint-Gilloise | -:- |
| 16-9-25 21:00 | Tottenham Hotspur | FC Villarreal | -:- |
| 16-9-25 21:00 | Benfica Lissabon | Qarabag | -:- |
| 16-9-25 21:00 | Juventus Turin | Borussia Dortmund | -:- |
| 16-9-25 21:00 | Real Madrid | Olympique Marseille | -:- |
| 17-9-25 18:45 | Olympiakos Piräus | Pafos FC | -:- |
| 17-9-25 18:45 | Slavia Prag | FK Bodö/Glimt | -:- |
| 17-9-25 21:00 | Paris St. Germain | Atalanta Bergamo | -:- |
| 17-9-25 21:00 | FC Liverpool | Atletico Madrid | -:- |
| 17-9-25 21:00 | Ajax Amsterdam | Inter Mailand | -:- |
| 17-9-25 21:00 | FC Bayern München | FC Chelsea | -:- |
| 18-9-25 18:45 | Club Brugge | AS Monaco | -:- |
| 18-9-25 18:45 | FC Kopenhagen | Bayer 04 Leverkusen | -:- |
| 18-9-25 21:00 | Sporting Lissabon | Qairat Almaty | -:- |
| 18-9-25 21:00 | Eintracht Frankfurt | Galatasaray Istanbul | -:- |
| 18-9-25 21:00 | Manchester City | SSC Neapel | -:- |
| 18-9-25 21:00 | Newcastle United | FC Barcelona | -:- |