| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 21-10-25 18:45 | FC Barcelona | Olympiakos Piräus | 6:1 |
| 21-10-25 18:45 | Kairat Almaty | Pafos FC | 0:0 |
| 21-10-25 21:00 | PSV Eindhoven | SSC Neapel | 6:2 |
| 21-10-25 21:00 | FC Villarreal | Manchester City | 0:2 |
| 21-10-25 21:00 | FC Kopenhagen | Borussia Dortmund | 2:4 |
| 21-10-25 21:00 | Royale Union Saint-Gilloise | Inter Mailand | 0:4 |
| 21-10-25 21:00 | FC Arsenal | Atletico Madrid | 4:0 |
| 21-10-25 21:00 | Newcastle United | Benfica Lissabon | 3:0 |
| 21-10-25 21:00 | Bayer 04 Leverkusen | Paris St. Germain | 2:7 |
| 22-10-25 18:45 | Galatasaray Istanbul | FK Bodö/Glimt | 3:1 |
| 22-10-25 18:45 | Athletic Bilbao | Qarabag | 3:1 |
| 22-10-25 21:00 | Real Madrid | Juventus Turin | 1:0 |
| 22-10-25 21:00 | FC Bayern München | Club Brugge | 4:0 |
| 22-10-25 21:00 | FC Chelsea | Ajax Amsterdam | 5:1 |
| 22-10-25 21:00 | Eintracht Frankfurt | FC Liverpool | 1:5 |
| 22-10-25 21:00 | Atalanta Bergamo | Slavia Prag | 0:0 |
| 22-10-25 21:00 | Sporting Lissabon | Olympique Marseille | 2:1 |
| 22-10-25 21:00 | AS Monaco | Tottenham Hotspur | 0:0 |